Different water solubility profile

It is basic science that an oil-based substance is expected to separate out when mixed with water. Oil-based CBD is generally known to separate out in a solution containing water. To a large extent, this observation has affected the general use of this product. Water-soluble CBD is generally preferred by consumers as it is miscible with water. This desirable property explains the basis for the increased use of water-soluble CBD as an additive in foods, drinks, beverages, and water-based cosmetics products. By mixing properly with water, water-soluble CBD creates an almost homogenous mix and help the consumer avoid the oily mess created by oil-based CBD.   


Different stability profile

In medical science, cannabidiol is expected to be presented as a stable product for safe storage. In the crude form, cannabidiol is extracted from hemp as oil-based CBD. The stability of this product is largely dependent on storage conditions and environmental factors. In producing water-soluble cannabidiol, the production science involved increases the stability of the finished product. Using microencapsulation techniques, the particulate CBD sample is encapsulated in a non-toxic material that mixes properly with water and also ensures that the CBD remains stable in its new form. Water-soluble CBD can also be presented as liposomes and microemulsion to increase product stability. 



Different bioavailability profile

Orally consumed oil-based CBD is subjected to the First Pass Effect. This biological phenomenon decreases the concentration of the product reaching the systemic circulation. To derive maximum therapeutic effect from CBD consumption, many cannabis companies, and pharmaceutical companies now present CBD in a water-soluble formulation. Converting crude oil-based CBD into water-soluble CBD also increases the number of methods available to consume CBD. 

In the pharmaceutical sciences, drugs are expected to be presented in a formulation that ensures the drug product mixes readily with water and oil. In essence, the drug is expected to have an impressive hydrophilicity/lipophilicity balance. Water-soluble CBD is essentially a CBD oil presented in a formulation that mixes easily with water. Compared to oil-based CBD, water-soluble CBD mixes readily in both phases. This explains the increased absorption of water-soluble in the body. 

Both water-soluble CBD and oil-based CBD contain CBD, however, in different formulations. The difference between both formulations is simply based on the mode of extraction and the processes involved in the production. Oil-based CBD is the conventional method of consuming cannabidiol in different parts of the globe. However, presenting cannabidiol as a water-soluble formulation increases the methods by which CBD and cannabis-derived products can be presented for consumption.



Anthony Tribunella

Having experienced the benefits of CBD first hand when it was starting to gain popularity, Anthony decided to spend his working life championing it to the public and his peers in the wider CBD community. As a CBD innovator himself, Anthony likes to remain at the leading edge of scientific and product development to ensure that the potential of CBD has every chance of being fully realized.

See all posts by Anthony Tribunella

Participate in CBD Research

CBD World News is part of an active community, working to enhance our understanding of the benefits of CBD. You can become an active part of that community too, by taking part in our collaborative research. We are interested in finding out who is using CBD, how it is used, and what it is used for?

Taking part in this research will help bring the good word of CBD to life and help people all over the world discover the benefits of cannabinoids.