The Use of Nanotechnology in CBD

Nanotechnology and drug delivery systems in the health industry

Innovations in drug delivery methods have increased tremendously over the past couple of decades. Pharmaceutical industries and biotechnological institutes have channeled billions of dollars into funding researches focused on developing and optimizing drug delivery. In a bid to stay ahead of the competition, many companies have developed and patented viable drug delivery options with impressive profiles. In all methods developed, the main objective was based on delivering precise quantities of drugs in the active forms to the appropriate target site in the biological system. It is common to now find journal and review papers published on the optimized delivery system developed based on implants, nanoparticles, transdermal drug delivery, liposomes polymers, and microencapsulation.    

Drug delivery systems increase the bioavailability of the active molecule and also maintain plasma levels of the delivered molecule. By releasing the drug directly to a predetermined target point, the rate of redistribution to other receptors or enzymes system is reduced—an action that significantly decreases adverse drug effects. An efficient delivery system also decreases the total amount of drug contained in a single dose while also improving patients’ compliance by reducing the frequency of drug administration. The benefits of new, innovative drug delivery systems are numerous and of great value to modern medicine. In large part, it opens up a new platform for the development of new alternative presentation forms for drug molecules with a short therapeutic window. 

Nanotechnology involves the presentation of matter on a molecular, atomic, or supramolecular scale for the design, production, and characterization of nanoscale materials. Compared to a standard drop of liquid, the nanoscale material measures a one-billionth length with a factor of 0.000000001. Nanotechnology provides novel technological advances with enhanced applications in the field of medicine: nanomedicine. The nanotherapeutic approach to drug delivery increases the stability of and water-soluble of drugs, reduces ate of enzyme degradation, increases the rate of tissue uptake, and improve drug safety and efficacy. Commonly known as the “science of small,” this technology is applicable to the delivery of both synthetic and natural products. 

Conventional drug delivery systems in the cannabidiol industry

The global push for cannabis legalization for medical and recreational purposes has prompted investments into the cannabis industry. Pharmaceutical companies have started clinical trials and developed innovative design methods for brands of CBD-based products sold as drugs or dietary supplements. With a growing base of cannabis users across the globe, cannabis products are now available in different presentations using many delivery systems for precise and optimal drug dosing. Currently, the conventional delivery systems available for cannabidiol products are not optimally efficient for cannabinoid delivery. 

While consumers need more efficient systems, cannabidiol companies are required by law to comply with regulations guiding the maximum quantity of cannabinoid available in a unit dose. The most popular conventional delivery methods for cannabinoids are based on the topical and oral delivery systems. These methods have limited efficiency and can only deliver a fractional share of the total cannabinoid dose into the bloodstream. Transdermal delivery systems using dermal patches and infused oils are only available for local applications directly on the skin. In recent times, the collaboration between the cannabinoid industries and the pharmaceutical companies have witnessed the introduction of innovative delivery systems aimed at supplying more cannabinoids are into the biological systems.

NanoZorb™ technology

NanoZorb™ technology is a delivery system based primarily on the principles of nanotechnology. Designed as an optimized delivery system, the NanoZorb™ technology is known to ensure superior stability and particle size at 100-150 nanometers. Basically, the processes involved in this patented technology yields enhanced solubilization of compounds and reduced micro-sized to nano-sized particles. The miniaturization technique reduces the particle size available in each unit of formulation to a scale that promotes enhanced absorption. For a technology providing benefits on such a scale, NanoZorb™ is indeed the ultimate of the science of small particles for big impacts. 

As part of the NanoZorb™ techniques of production, the miniaturized particles are subsequently stabilized against agglomeration by surface absorption of selected stabilizers. These stabilizers are Generally Recognized As Safe (GRAS) and, as such, preserves the particles’ integrity, safety, and purity. At the end of these extensive processes, the particles are presented as a dispersible liquid nano-suspension, which are biologically stable and can be administered through different routes. On the engineering scale, the process involved in producing the final output is complex. Described as a cold process, NanoZorb™ technology passes the formulation under production through a fixed geometry microchannels within an interaction chamber.

In this chamber, the in-process formulation is accelerated to a high velocity creating a high magnitude shear rate that breakdown the into miniature particles. Unlike other methods of creating miniaturized particles with an impressive absorption profile, the procedures involved in the NanoZorb™ technology processes create uniform particles using high acceleration and not heat. 

Prospects of NanoZorb™ technology in the global cannabinoid industry

NanoZorb™ technology simply offers an impressive improvement in all other nanotechnology processes currently available in the product market. The NanoZorb™ CBD improves users’ experience by providing an optimally absorbable cannabinoid using new innovation in production science. By creating a fine interplay between modern technology and natural product science, NanoZorb™ technology can help cannabis companies increase the bioavailability of CBD with the necessarily increasing quantity of CBD or cannabis extract in a single dose. The stability profile of CBD is also improved using this technology. 

With a stable formulation, the shelf life of CBD-based products is also enhanced. Absorption is improved, and the quantity of CBD available per time in the bloodstream is dramatically increased. In the medical sciences, this technology produces nano-sized particles that can easily penetrate the cell membranes and reach maximum concentration levels in target systems at minimal time. With regard to all these properties, the activity of a CBD formulation prepared using NanoZorb™ technology is greatly improved. 

If widely used in the global cannabinoid industry, NanoZorb™ technology is capable of revolutionizing cannabidiol use for medical and recreational purposes. You can find out more about the brands making the most of NanoZorb™ technology at www.cbdproducts.com.

REFERENCES

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520586/
• https://www.maxverawellness.com/what-is-NanoZorb™
• https://www.frontiers.org/articles/10.3389/fbioe.2019.00489/full
• https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-018-0392-8
• https://www.cannabissciencetech.com/view/how-cannabis-industry-can-benefit-leveraging-pharmaceutical-resources
• https://www.intechopen.com/books/application-of-nanotechnology-in-drug-delivery/application-of-nanotechnology-in-drug-delivery